Glutathione and Glutamate Levels in the Diaphragm of Patients with Chronic Obstructive Pulmonary Disease
Posted: Monday. May 19, 2008
Recently, decreased glutamate (Glu) and reduced glutathione (GSH) levels were reported in the quadriceps femoris of patients with chronic obstructive pulmonary disease (COPD). The aim of the present study was to investigate whether Glu and GSH levels are also modified in the diaphragm of these patients. Nine male COPD patients (forced expiratory volume in one second (FEV1) range 28-68% of the predicted value) and seven male patients with normal pulmonary function (mean SD FEV1 86 3% pred) submitted to thoracotomy were included.