Daily Archives for: August 18th, 2008

Magnesium for Delayed Cerebral Ischemia in Aneurysmal Subarachnoid Hemorrhage: Time for a Paradigm Shift?

Posted: Monday. August 18, 2008

To the Editor:

The Magnesium Sulphate in Aneurysmal Subarachnoid Hemorrhage (MASH) study group investigated continuous intravenous magnesium sulfate infusion from days 4 to 14 after subarachnoid hemorrhage (SAH); the clinical outcome of reduction of delayed cerebral ischemia (DCI) remains, however, uncertain.1 It is generally believed that magnesium supplementation reverses vasospasm and offers neuroprotection to ischemic brain tissues.

Magnesium Intake and the Metabolic Syndrome: Epidemiologic Evidence to Date

Posted: Monday. August 18, 2008

The importance of magnesium intake in relation to the metabolic syndrome has been increasingly recognized. Magnesium is an essential mineral, critical for a number of metabolic functions in the human body. The major dietary sources of magnesium intake include whole grains, legumes, nuts, and green leafy vegetables. Animal studies indicate a pivotal role of magnesium in glucose homeostasis and insulin secretion and action.

The use of magnesium sulfate in acute asthma: Rapid uptake of evidence in North American emergency departments

Posted: Monday. August 18, 2008

Background Systematic reviews of approximately 13 randomized trials support results with intravenous magnesium sulfate (MgSO4) in patients with severe acute asthma; however, little is known about its actual clinical use.

Objective We sought to examine the use of intravenous MgSO4 in the emergency department (ED) and physician attitudes toward its use.

Oral Results With -Lipoic Acid Improves Symptomatic Diabetic Polyneuropathy

Posted: Monday. August 18, 2008

OBJECTIVE—The aim of this trial was to evaluate the effects of {alpha} -lipoic acid (ALA) on positive sensory symptoms and neuropathic deficits in diabetic patients with distal symmetric polyneuropathy (DSP).

RESEARCH DESIGN AND METHODS—In this multicenter, randomized, double-blind, placebo-controlled trial, 181 diabetic patients in Russia and Israel received once-daily oral doses of 600 mg (n = 45) (ALA600),

Lipoic Acid Prevents the Increase in Atherosclerosis Induced by Diabetes in Apolipoprotein EÐ²Ð‚â€œDeficient Mice Fed High-Fat/Low-Cholesterol Diet

Posted: Monday. August 18, 2008

Considerable evidence indicates that hyperglycemia increases oxidative stress and contributes to the increased incidence of atherosclerosis and cardiovascular complications in diabetic patients. To examine the effect of -lipoic acid, a potent natural antioxidant, on atherosclerosis in diabetic mice, 3-month-old apolipoprotein (apo) E-deficient (apoE–/–) mice were made diabetic by administering streptozotocin (STZ). At 4 weeks after starting the STZ administration,

Effects of Alpha-Lipoic Acid Supplementation in Peripheral Arterial Disease: A Pilot Study

Posted: Monday. August 18, 2008

Objective: To examine whether 3 months of lipoic acid (LA) supplementation improved walking tolerance and delayed claudication pain onset in peripheral arterial disease (PAD).

Design: Randomized, double-blind, controlled study.

Setting: General Clinical Research Center.

Subjects: Twenty-eight (28) participants (15 men, 13 women) with PAD (ankle brachial index range 0.9–0.4,

Lipoic Acid and Cardiovascular Disease1

Posted: Monday. August 18, 2008

Lipoic acid (ALA) has been identified as a powerful antioxidant found naturally in our diets, but appears to have increased functional capacity when given as a supplement in the form of a natural or synthetic isolate. ALA and its active reduced counterpart, dihydrolipoic acid (DHLA), have been shown to combat oxidative stress by quenching a variety of reactive oxygen species (ROS).

Acetyl-L-carnitine and ?-lipoic acid: possible neurotherapeutic agents for mood disorders?

Posted: Monday. August 18, 2008

Background: Mood disorders are associated with decrements in cognitive function, which are insufficiently treated with contemporary pharmacotherapies.

Objectives: To evaluate the putative neurotherapeutic effects of the mitochondrial cofactors, L-carnitine, acetyl-L-carnitine, and α-lipoic acid; and to provide a rationale for investigating their efficacy in the results of neurocognitive deficits associated with mood disorders.

Effects of Diabetes, Insulin and Alpha-Lipoic Acid on Diabetic Myopathy

Posted: Monday. August 18, 2008

Background and Aims: The progression of diabetes mellitus is concomitant with decrease of the regenerative capacity of skeletal muscle and results with insulin can prevent futher atrophy of slow and fast skeletal muscles. The aim of this study was to explore the effectss of type 1 diabetes and its results with insulin plus antioxidant (alpha-lipoic acid –

Lipoic Acid as a Potential for Chronic Diseases Associated with Oxidative Stress

Posted: Monday. August 18, 2008

-Lipoic acid (LA), a naturally occurring dithiol compound, has long been known as an essential cofactor for mitochondrial bioenergetic enzymes. Aside from its enzymatic role, in vitro and in vivo studies suggest that LA also acts as a powerful micronutrient with diverse pharmacologic and antioxidant properties.

Pharmacolo-gically, LA improves glycemic control,

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