We evaluated the association between potential occupational lead exposure and the risk of brain cancer mortality in the National Longitudinal Mortality Study (NLMS), which is a prospective census-based cohort study of mortality among the noninstitutionalized United States population (1979-1989). The present study was limited to individuals for whom occupation and industry were available (n = 317,968).
The International Agency for Research on Cancer recently classified inorganic lead as a probable carcinogen,
while organic lead remained unclassifiable. Uncertainty persists because of limited epidemiologic evidence. The
authors addressed the relation between occupational exposure to lead and the risk of 11 types of cancer among
men in a case-control study conducted in Montreal,
DNA methylation is an epigenetic mark which regulates gene expression and can be modified by environmental factors, possibly including toxic metals. Although their function is unclear, DNA contains large numbers of interdispersed repetitive elements (ALU and LINE-1) that are normally heavily methylated. Global methylation can be measured within these elements and changes in global methylation have been associated with diseases such as cancer and cardiovascular disease.
In order to investigate the toxic effects of lead during occupational exposure to this metal and the antidotal efficacy of ascorbic acid directed against these toxic effects, various artisans in Abeokuta, Nigeria, who have been shown to be occupationally exposed to lead were supplemented daily with 500 mg ascorbic acid for 2 weeks.
Prenatal and early-life exposure to lead is hypothesized to have a range of adverse effects on childhood health. Drawing on data collected from a population-based prospective cohort study of a highly exposed town and a low exposed town in Kosovo, Yugoslavia we assessed whether elevated maternal blood lead (BPb) concentrations during pregnancy were associated with reduced childhood measures of attained height and BMI or growth rate,
Low levels of chronic lead exposure can produce hypertension and endothelial dysfunction, which could be associated with oxidative stress, changes in vascular tone and an imbalance of endothelial-derived vasoconstriction and vasodilator factors. The aim was to investigate the effect of chronic lead-exposure on angiotensin II-induced vasoconstriction in isolated perfused kidney and microvessels. Male Wistar rats (230—250 g) were treated for 12 weeks with lead acetate (100 ppm,
Chronic exposure to low doses of lead results in generation of reactive oxygen species, reduced nitric oxide availability, and arterial hypertension. The present studies were done to define if other conditions associated with oxidative stress, such as renal interstitial inflammation, nuclear factor-κB (NF-κB) activation, and cells expressing angiotensin II, are, in fact, features of low-dose lead exposure.
The activity response of the antioxidant enzymes glutathione peroxidase (GPx), glutathione reductase (GR) and the contents of thiobarbituric reactive substances (TBARS) were investigated in rats exposed to lead. The enzyme activities were determined in the liver, kidney and heart of male and female rats which were received 100 mg and 1000 mg of lead acetate per liter water for 18 weeks.
Cadmium induces hypertension in animal models. Epidemiologic studies of cadmium exposure and hypertension, however, have been inconsistent.
We aimed to investigate the association of blood and urine cadmium with blood pressure levels and with the prevalence of hypertension in U.S. adults who participated in the 1999–2004 National Health and Nutrition Examination Survey (NHANES).
Abstract: The aim of this study was to estimate the activity of superoxide dismutase (SOD) and catalase in
erythrocytes and malondialdehyde (MDA) in plasma of battery manufacturing workers (BMW) of Western
Maharashtra (India) who were occupationally exposed to lead (Pb) over a long period of time (about 15 years). This
study was also aimed to determine the Pb intoxication resulted in a disturbance of heme biosynthesis in BMW group.