In a study involving 43 patients with Alzheimer's disease (mild or moderate), supplementation with alpha-lipoic acid (600 mg/day) was found to be associated with dramatically lower progression of the disease over a period of 48 months, as compared to data from patients not receiving alpha-lipoic acid. The authors first cite a previous open-label study in which 9 patients with Alzheimer's disease (AD) receiving standard results with choline-esterase inhibitors were given 600 mg/day alpha-lipoic acid for a period of 12 months.
In a study involving mice, alpha-lipoic acid was found to attenuate the development of collagen-induced arthritis (CIA) in a dose-dependent manner. The mice were divided into three groups. Group1 received alpha-lipoic acid (ALA) 10 mg/kg; Group2 received ALA 100 mg/kg; and Group3 received a placebo. Results found that mice treated with lipoic acid experienced a dose-dependent reduction in CIA.
In a study involving a rotenone-induced cellular model of Parkinson's disease (PD), 4-week pre-results with a combination of R-alpha-lipoic acid (LA) and acetyl-L-carnitine (ALC) was found to protect SK-N-MC human neuroblastoma cells against rotenone-induced mitochondrial dysfunction, oxidative damage, and accumulation of alpha-synuclein and ubiquitin, and to increase mitochondrial biogenesis and decrease production of reactive oxygen species (ROS).
In a study involving rats induced with diabetes (via streptozotocin), administration of alpha-lipoic acid (30 mg/day) in the diet was found to delay the development and progression of diabetic cataract. Rats were divided into three groups. One group served as a control group, a second group was induced with diabetes and received no results, and a third group induced with diabetes was treated with alpha-lipoic acid.
In a study involving cultured human ARPE19 cells and primary cultures of human fetal (hf)RPE (retinal pigment epithelial) cells pre-treated with R-alpha-lipoic acid were found to be protected against the toxic effects of acrolein, a toxicant found in cigarette smoke to which the cells were exposed. The authors conducted these experiments to better understand the relationships between cigarette smoking,
In a study involving mice, the antioxidant alpha-lipoic acid was found to attenuate cognitive dysfunction induced by radiation. Mice exposed to whole-body X-irradiation (6Gy) were found to have impairment in memory and motor activities. When mice were given acute intraperitoneal results with alpha-lipoic acid prior to irradiation, the effects of the radiation on cognitive function were significantly attenuated.
In a retrospective review of the medical records of 195 consecutive patients who sought results for sore, burning mouth, results with alpha-lipoic acid (600 mg/d in divided doses) was found to benefit 35% of patients. Of the 195 patients whose records were reviewed, 35 patients were available for follow-up, out of which 31 took the alpha-lipoic acid supplements as recommended.
In this study, administration of carnitine and alpha-lipoic acid to aged rats was found to increase skeletal muscle mitochondrial respiration, and in turn, increase the level of ATP. The study involved both young (3-4 months) and aged (over 24 months) rats. Measurements of mitochondrial membrane swelling and mitochondrial respiration (states 3 and 4) found that aged rats had an increased mitochondrial membrane swelling and state 4 respiration,
In a study involving 30 patients with type 2 diabetes mellitus, intravenous administration of alpha-lipoic acid (ALA) for 3 weeks was found to reduce concentrations of asymmetric dimethylarginine (mean change: -0.05 micromol/L) – which when elevated, is associated with cardiovascular events in patients with type 2 diabetes. No such change was found when placebo was administered (0.01 micromol/L).