In a study of 37 multiple sclerosis patients, subjects were randomized to 4 groups, including placebo (2 male and 7 female subjects, median age 50 years); alpha lipoic acid at 600 mg, 2 times daily (1 male and 6 female subjects, median age 49 years); alpha lipoic acid at 1,200 mg, once daily (1 male and 8 female subjects,
In a study involving a rd1 mouse model of retinitis pigmentosa (RP) – a group of diseases which involve damage to the retina, and are caused by a large number of mutations that result in rod photoreceptor cell death, which is followed by a gradual death of cones, the mechanism of which is unknown, characterized by decreased or loss of night vision,
Three patients were selected at random from a group of approximately 50 chronic hepatitis C patients. Each patient was maintained on a dose of 600 mg of alpha-lipoic acid per day in 2 divided doses of 300 mg, as well as silymarin at 900 mg/day in 3 divided doses of 300 mg and selenomethionine at 400 ug/day in 2 divided portions of 200 ug.
In an open early-phase II study involving 44 patients with advanced cancer, adherence to a regimen including high amounts of dietary and supplementary antioxidants was found to increase body weight, lean body mass, and appetite, decrease proinflammatory cytokines (IL-6 and TNF-alpha), and improve quality of life, over a period of 4 months. Of the 44 patients who began the study,
The central mechanism of neurodegeneration for autoimmune diseases, viral encephalitis, Lyme disease, AIDS dementia syndrome, brain injury, strokes, heavy metal toxicity, spongiform encephalitis, and diseases such as Alzheimer's dementia, Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis is similar. The mechanism is a combination of excitotoxic injury in conjunction with free radical damage to neural tissue.
Fasting mongrel dogs underwent hyperbaric oxygen results (HBOT), recombinant tissue plasminogen activator (rt-PA) results, and simultaneous HBOT and rt-PA results following prior experimental left anterior descending coronary artery occlusion for 2 hours. Thrombosis in and around a copper coil was recorded angiographically at regular intervals, and immediately prior to results conclusion. Controls (n = 10) were untreated.
Therapeutic irradiation is commonly used to treat clinically localized prostate cancer. Although radiation is effective for localized prostate cancer, the rectum is often affected because of its proximity to the treated tumour. The incidence of severe chronic radiation proctitis induced by pelvic irradiation is reported to be 2–5%. The symptoms of chronic radiation proctitis include diarrhoea,
BACKGROUND: There is no effective results for chronic traumatic, ischemic, hypoxic, and anoxic brain injuries. We report the initial success of low pressure (LP) HBOT in their results. METHODS: All referrals with chronic stable encephalopathies manifested by perfusion/metabolism deficits on HMPAO SPECT scans that improved on repeat scan immediately after a 1. 5 or 1.75 ATA/90 min HBOT were included.
OBJECTIVE: To evaluate the effectiveness of systemic hyperbaric oxygen (s HBOT) in addition to a comprehensive protocol in decreasing major amputation rate in diabetic patients hospitalized for severe foot ulcer. RESEARCH DESIGN AND METHODS: From August 1993 to August 1995, 70 diabetic subjects were consecutively admitted into our diabetologic unit for foot ulcers. All the subjects underwent our diagnostic-therapeutic protocol and were randomized to undergo s-HBOT.
Background: The results of pelvic malignancies (uterine, cervix, rectum, etc) often include radiation. Radiation-induced late side effects (longer than 3 months) are developed in 5–10% of those patients. We wanted to investigate the efficacy of hyperbaric oxygen (HBOT) in the management of those patients. Methods: Thirteen women were evaluated.
