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Daily Archives for: June 8th, 2013


Epidemiologic evidence suggests diets rich in cruciferous vegetables, particularly broccoli, are associated with lower bladder cancer risk. Our objectives are to investigate these observations and determine the role of isothiocyanates in primary or secondary bladder cancer prevention.

Methods and results

We initially investigate the mechanisms whereby broccoli and broccoli sprout extracts and pure isothiocyanates inhibit normal,

In the present studies, we utilized prostate cancer cell culture models to elucidate the mechanisms of action of broccoli-derived phytochemicals 3,3′-diindolylmethane (DIM) and indole-3-carbinol (I3C). We found DIM and I3C at 1–5 µM inhibited androgen and estrogen-mediated pathways and induced xenobiotic metabolism pathway. By contrast, DIM and I3C induced cyclin inhibitors, indicators of stress/DNA damage,

Evidence from epidemiologic studies has suggested that carotenoids, and lycopene in particular, decrease the risk of cancer: however, not all studies support this view. To gain insight into the molecular mechanisms whereby lycopene and other carotenoids may exert their chemoprotective effects, we and others performed a series of studies that used a large panel of cancer cell lines of different lineages and animal models of human cancer.

Lycopene, a red pigmented carotenoid present in many fruits and vegetables such as tomatoes, has been associated with the reduced risk of breast cancer. This study sought to identify proteins modulated by lycopene during cell proliferation of the breast cancer cell line MCF-7 to gain an understanding into its mechanism of action. MCF-7 breast cancer cells and MCF-10 normal breast cells were treated with 0,

Epidemiological and human clinical trials suggest that dietary intake of tomatoes or lycopene protects against cancers of the prostate, breast, cervix, ovary, endometrium, lung, bladder, oral cavity, esophagus, stomach, colon, and pancreas.

Lycopene, a major carotenoid component of tomato, has a potential anticancer activity in many types of cancer. Epidemiological and clinical trials rarely provide evidence for mechanisms of the compound’s action, and studies on its effect on cancer of different cell origins are now being done. The aim of the present study was to determine the effect of lycopene on cell cycle and cell viability in eight human cancer cell lines.

The incidence of cancer is rising in almost all parts of the world because of changes in the environment, changes in life style and food habits as well as due to growing industrialization and modernization. UV exposures from the sun in the exposed areas of the body are the prime locations of developing skin cancer.

Key Points

1. Research during the past decade has provided a wealth of evidence that links garlic intake and its associated sulfur compounds as an important deterrent to cancer.

2. Both water- and lipid-sulfur allyl sulfur compounds appear to account for much of garlic’s anticarcinogenic and antitumorigenic properties.

3. Some of the strongest evidence comes from preclinical models where garlic and its constituents have been found to retard chemically induced cancer at multiple sites as well as to inhibit proliferation and induce apoptosis of established human and murine cell lines.

Allicin (diallyl thiosulfinate) is the best-known biologically active component in freshly crushed garlic extract. We developed a novel, simple method to isolate active allicin, which yielded a stable compound in aqueous solution amenable for use in in vitro and in vivo studies. We focused on the in vitro effects of allicin on cell proliferation of colon cancer cell lines HCT-116,