Metformin, widely given to patients with type 2 diabetes, works by targeting the enzyme AMPK (AMP activated protein kinase), which induces muscles to take up glucose from the blood. A recent breakthrough has found the upstream regulator of AMPK to be a protein kinase known as LKB1. LKB1 is a well recognised tumour suppressor. Activation of AMPK by metformin and exercise requires LKB1, and this would also explain why exercise is beneficial in the primary and secondary prevention of certain cancers.We hypothesise that metformin use in patients with type 2 diabetes may reduce their risk of cancer.
Understanding Intradermal Skin Testing: How We Pinpoint Your Allergens
Many health concerns begin with questions about allergies, and a clear diagnosis often starts with testing. Symptoms like nasal congestion,
