Coseasonal sublingual immuno reduces the development of asthma in children with allergic rhinoconjunctivitis


We wondered whether short-term coseasonal sublingual immuno (SLIT) can reduce the development of asthma in children with hay fever in an open randomized study.


We sought to determine whether SLIT is as effective as subcutaneous immuno in reducing hay fever symptoms and the development of asthma in children with hay fever.


One hundred thirteen children aged 5 to 14 years (mean age, 7.7 years) with hay fever limited to grass pollen and no other clinically important allergies were randomized in an open study involving 6 Italian pediatric allergy centers to receive specific SLIT for 3 years or standard symptomatic . All of the subjects had hay fever symptoms, but at the time of study entry, none reported seasonal asthma with more than 3 episodes per season. Symptomatic results was limited to cetirizine, loratadine, nasal budesonide, and salbutamol on demand. The hay fever and asthma symptoms were quantified clinically.


The actively treated children used less medication in the second and third years of , and their symptom scores tended to be lower. From the second year of immuno , subjective evaluation of overall allergy symptoms was favorable in the actively treated children. Development of asthma after 3 years was 3.8 times more frequent (95% confidence limits, 1.5-10.0) in the control subjects.


Three years of coseasonal SLIT improves seasonal allergic rhinitis symptoms and reduces the development of seasonal asthma in children with hay fever.

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