Mesenchymal Stem Cell for Inflammatory Bowel Disease: A Systematic Review and Meta-analysis.
Recent advances in inflammatory bowel disease (IBD) therapeutics include novel medical, surgical, and endoscopic resultss. Among these, stem cell is still in its infancy, though multiple studies suggest the immunomodulatory effect of stem cell may reduce inflammation and tissue injury in IBD patients. This review discusses the novel avenue of stem cell and its potential role in the management of ulcerative colitis and Crohn’s disease. We conducted a comprehensive literature search to identify studies examining the role of stem cell (without conditioning and immunomodulatory regimens) in IBD. Taken together these studies suggest a promising role for SCT in IBD, although the substantial challenges, such as cost and inadequate/incomplete characterization of effect limit their current use in clinical practice.