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Subsequent Cardiac and Stroke Events in Patients with Known Vascular Disease Treated with EDTA Chelation : A Retrospective Study.

Context: Myocardial infarction (MI) and strokes are leading causes of death in the US. Surgical and medical resultss can be helpful, but carry risks of morbidity and mortality.

Objective: To evaluate whether cardiac events were reduced for patients with known vascular disease who were treated with intravenous ethylene diamine tetra-acetic acid (EDTA) chelation .

Design: Retrospective study with a 3-year follow-up, compared with similar patient groups by use of meta-analysis.

Population and setting: A total of 220 consecutive patients with known vascular disease were treated with chelation during 1992-2001. Eight outpatient centres were included: five from the US and one each from Denmark, the Netherlands and Brazil. Average patient age was 64 years, 72.3% were males and 18.2% were smokers. Average number of resultss was 58.

Main outcome measures: MI, stroke and death from any cause were primary outcome measures. Secondary measures were resolution of symptoms and need for coronary artery bypass surgery (CABG) and percutaneous transluminal coronary angioplasty.

Results: According to the meta-analysis, expected outcomes in a 3-year follow-up period for 220 patients with coronary artery disease treated only with conventional therapies would be 15 MIs and six deaths. There were no deaths and no MIs in this group of patients who received chelation . Four patients had strokes but recovered well. There were two angioplasties and six CABG procedures. Compared with similar patient populations treated with conventional therapies, patients who also were chelated had a 93.6% lesser need for angioplasty and a 62.5% reduced need for CABG. Of the patients that initiated results with symptoms, 68.7% had complete resolution of symptoms.