Dietary arsenic intake estimates based on surveys of total arsenic concentrations appear to be dominated by intake of the relatively non-toxic, organic arsenic forms found in seafood. Concentrations of inorganic arsenic in food have not been not well characterized. Accurate dietary intake estimates for inorganic arsenic are needed to support studies of arsenic's status as an essential nutrient,
Metals such as aluminum (Al), copper (Cu), zinc and iron have been implicated in the pathogenesis of Alzheimer's disease (AD). Because trace amounts of metals are present in the drinking water, there is a possibility for low-dose chronic exposure. Since the presence of Al and Cu in drinking water has been shown to adversely affect the progression of AD,
Abstract Gulf War illness (GWI) affects a significant percentage of veterans of the 1991 conflict, but its origin remains unknown. Associated with some cases of GWI are increased incidences of amyotrophic lateral sclerosis and other neurological disorders. Whereas many environmental factors have been linked to GWI, the role of the anthrax vaccine has come under increasing scrutiny.
Background. Several epidemiologic studies have suggested an association between Parkinson’s disease (PD) and exposure to heavy metals using subjective exposure measurements.
Objectives. We investigated the association between objective chronic occupational lead exposure and the risk of PD.
Methods. We enrolled 121 PD patients and 414 age-,
Mounting evidence is demonstrating roles for the amyloid precursor protein (APP) and its proteolytic product Aβ in metal homeostasis. Furthermore, aberrant metal homeostasis is observed in patients with Alzheimer's disease (AD), and this may contribute to AD pathogenesis, by enhancing the formation of reactive oxygen species and toxic Aβ oligomers and facilitating the formation of the hallmark amyloid deposits in AD brain.
Glutathione depletion occurs in several forms of apoptosis and is associated with Parkinson's disease and HIV toxicity. The neurotransmitter glutamate kills immature cortical neurons and a hippocampal nerve cell line via an oxidative pathway associated with glutathione depletion. It is shown here that soluble guanylyl cyclase (sGC) activity is required for nerve cell death caused by glutathione depletion.
We wondered whether short-term coseasonal sublingual immuno (SLIT) can reduce the development of asthma in children with hay fever in an open randomized study.
We sought to determine whether SLIT is as effective as subcutaneous immuno in reducing hay fever symptoms and the development of asthma in children with hay fever.
Background Subcutaneous immuno for respiratory allergy has shown a long-lasting efficacy after its discontinuation, whereas this evidence is still lacking for sublingual immuno , despite the fact that it is widely used.
Objective We aimed to evaluate whether a long-lasting effect of SLIT occurs, in a prospective parallel group controlled study.
Fifty-eight patients with well-documented history of seasonal rhinoconjunctivitis caused by grass pollens were allocated randomly on a double-blind basis to receive either sublingual with a solution of purified, standardized allergen preparation (Stallergenes) or a matched placebo for 17 weeks.
The assessment of the effect of oral immuno , done with drops of five-grass allergen extract,
Background: Immuno is an established results of allergic diseases. The safety of this results, particularly when administered without direct medical surveillance, as in the case of the sublingual-swallow route needs to be established. The aim of this paper is to review the safety of the sublingual-swallow immuno as reported in eight double-blind,